Robust parameter adjustment with nonparametricweighted-ball-in-H∞ uncertainty

Using a parameter adjustment law, robust monotonic parameter error reduction is proved for a linear parameter estimation problem in which the signal is corrupted by the presence of nonparametric dynamical uncertainty. The nonparameterized dynamics are characterized by a known frequency-domain magnitude bound. A nonconservative bound on the finite-time energy of the nonparametric-dynamics output is constructed in real time. When the error single energy is small enough to be due to nonparametric dynamics alone, the parameter adjustment is shut off to avoid misadjustment. The approach is an extension of existing adaptive control error-dead-zone ideas to the case of frequency-domain bounded uncertainty     

High pressure extraction of oil seed

For calculation of phase equilibria of the system seed oil/CO₂, an equation of state published in the literature has been fitted to experimental data of that system. The results thus obtained are of only limited use in designing a supercritical extraction process. The experimental investigation of the mass transfer kinetics is much more significant. Mechanical processing of the oil seed’s cell wall structure has been shown to be of great importance. The best specific yields were achieved with material that had been mechanically pre-deoiled and thereby broken open. Yields are increased considerably by use of the gas mixture CO₂/propane or other special gas mixtures or by the addition of refrigerants. However, the extraction times achieved in batch operation, together with the mass product nature of oil seed, make a continuous supercritical extraction essential if operation is to become economic relative to the conventional hexane extraction. To this end, the energetics of the process have been calculated, and practical possibilities for continuous operation are discussed. Presented at the International Symposium, “High Pressure Chemical Engineering,” Erlangen, in October 1984.     

Exploring the Effects of Glycosylation and Etherification of the Side Chains of the Anticancer Drug Mitoxantrone

Herein we report the synthesis and biological evaluation of symmetric and asymmetric analogues of the DNA intercalating drug mitoxantrone (MTX) in which the side chains of the parent drug were modified through glycosylation or methyl etherification. Several analogues with glycosylated side chains exhibited higher DNA affinity than the parent MTX. The most potent in vitro cytotoxicity was observed for MTX analogue 8 (1,4‐dimethoxy‐5,8‐bis[2‐(2‐methoxyethylamino)ethylamino]anthracene‐9,10‐dione) with methoxy ether containing side chains. Treatment of melanoma‐bearing mice with MTX or analogue 8 decreased the intraperitoneal tumor burden relative to untreated mice; the effect of 8 was less pronounced than that of MTX. In vitro metabolism assays of MTX with rabbit liver S9 fraction gave rise to several metabolites; almost no metabolites were detected for MTX analogue 8 . The results presented indicate that derivatization of the MTX side chain primary hydroxy groups may result in a significant improvement in DNA affinity and lower susceptibility to the formation of potentially toxic metabolites.     

Attrition of porous glass particles in a fluidised bed

Fluidisation is frequently accompanied by unwanted attrition of the bed material. This paper focuses on the mechanical aspects of fines creation by attrition in fluidised beds supported by multi-orifice distributor plates. The attrition rates of low-density porous glass particles were measured; these particles show abrasive wear behaviour rather than breakage. Positron emission particle tracking (PEPT) was used to follow particle motion in three dimensions within the fluidised bed. For a single orifice distributor with background fluidisation, the attrition rate increased exponentially with increasing orifice gas velocity. For a multi-orifice distributor, however, attrition rates were roughly proportional to excess gas velocity, except near to a critical ratio of particle to orifice diameter; as this ratio approached 2, attrition was observed to increase by an order of magnitude. A method is proposed for estimating attrition rates from a combination of small-scale experimental results and theoretical calculations of distributor jet entrainment rates.     

Methods of Motor Current Signature Analysis

ABSTRACT

Recently a technique for monitoring and diagnosing mechanical problems, associated with rotating machines driven by electric motors, has been proposed and is now being offered by several commercial suppliers. This technique, known as “Motor Current Signature Analysis” or MCSA, seeks to apply much of the long experience in vibration signature analysis to the analysis of motor current in effect using the motor as a sensor akin to an acceleromeier This paper explores some of the history of the technique, presents several examples, and demonstrates a first order approach to the theory with associated cautions.     

Design of Low-Bandwidth Spatially Distributed Feedback

The paper considers a family of linear time-invariant and spatially invariant (LTSI) systems that are both distributed and localized. The spatial responses of the distributed plant are localized in spatial neighborhoods of each location. The feedback computations are also distributed and the information flow is localized in a spatial neighborhood of each location. The feedback is aimed at controlling spatial distributions of variables in the systems with a relatively low bandwidth in the time direction. Such systems have many important applications including industrial processes, imaging systems, signal and image processing, and others. We describe a new method for designing (tuning) a certain family of low-bandwidth controllers for such plants. We consider LTSI controllers with a fixed structure, which is a PID or a similar low-bandwidth feedback in time and local in spatial coordinates. Two spatial feedback filters, symmetric and with finite spatial response, modify the local PID control signal by mixing in the error and control signals at nearby nodes. These two filters provide loopshaping and regularization of the spatial feedback loop. Like an ordinary PID controller, this controller structure is simple, but provides adequate performance in many practical settings. We cast a variety of specifications on the steady-state spatial response of the controller and its time response as a set of linear inequalities on the design variables, and so can carry out the design of the spatial filters using linear programming. The method handles steady-state limits on actuator signals, error signals, and several constraints related to robustness to plant and controller variation. The method allows handling the effects of boundary conditions and guaranteed closed-loop spatial or time decay. It does appear to work very well for low-bandwidth controllers, and so is applicable in a variety of practical situations.      

Heritability of anxiety sensitivity: a twin study

OBJECTIVE: In attempting to explain the familial predisposition to panic disorder, most studies have focused on the heritability of physiologic characteristics (e.g., CO2 sensitivity). A heretofore unexplored possibility is that a psychological characteristic that predisposes to panic-anxiety sensitivity-might be inherited. In this study, the authors examined the heritability of anxiety sensitivity through use of a twin group. METHOD: Scores on the Anxiety Sensitivity Index were examined in a group of 179 monozygotic and 158 dizygotic twin pairs. Biometrical model fitting was conducted through use of standard statistical methods. RESULTS: Broad heritability estimate of the Anxiety Sensitivity Index as a unifactorial construct was 45%. Additive genetic effects and unique environmental effects emerged as the primary influences on anxiety sensitivity. There was no evidence of genetic discontinuity between normal and extreme scores on the Anxiety Sensitivity Index. CONCLUSIONS: This study suggests that one psychological risk factor for the development of panic disorder-anxiety sensitivity-may have a heritable component. As such, anxiety sensitivity should be considered in future research on the heritability of panic disorder.     

Benefits of a high‐performance phosphite in the gamma irradiation of polyolefins

The highly active process stabilizer bis(2,4‐dicumylphenyl)pentaerythritol diphosphite (P1) was compared in a series of polyolefin formulations with tris(2,4‐di‐t‐butylphenyl) phosphite (P2). Because of its high activity, there was less polymer degradation during processing with P1 as compared to P2. As a result, improvements in color and other physical properties were observed for the polymers, not only during processing, but also after treatment with gamma radiation.